The Preventive Effects of Adrenalectomy in Metha- nol Intoxication on Photoreceptors in Rabbit Retina (Oryctolagus cuniculus): Ultrastructural Study

Document Type : Original Article

Authors

1 Department of Basic Sciences of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

2 Department of Surgical Sciences of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

Abstract

In this work the protective effect of adrenalectomy against the methanol intoxication in photoreceptor layer of rabbit retina was studied. Fifteen female White New Zealand rabbits were used in this study, and were divided into three groups: Control group, Experimental group I (re- ceived 4 gram/ kilogram methanol), Experimental group II (adrenalec- tomized and received 4 gram/kilogram methanol). Then af- ter, the retina was separated and observed by transmission electron microscope.
The major sign of pathology such as outer segment loss, disorganized inner segment and condensed and pyknotic nuclei in outer nuclear lay- er of photoreceptor layer were seen in experimental group I. But normal photoreceptor layer were obvious in adrenalectomized animals in exper- imental group II.
These observations showed that the adrenalectomy could improve the damage of the photoreceptor layer of the retina against the oxidative stress of methanol intoxication.

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